Publications
2022
Ghigo A., Murabito A., Sala V., Pisano A.R., Bertolini S., Gianotti A., Caci E., Montresor A., Premchandar A., Pirozzi F., Ren K., Sala A.D., Mergiotti M., Richter W., de Poel E., Matthey M., Caldrer S., Cardone R.A., Civiletti F., Costamagna A., Quinney N.L., Butnarasu C., Visentin S., Ruggiero M.R., Baroni S., Crich S.G., Ramel D., Laffargue M., Tocchetti C.G., Levi R., Conti M., Lu X.-Y., Melotti P., Sorio C., De Rose V., Facchinetti F., Fanelli V., Wenzel D., Fleischmann B.K., Mall M.A., Beekman J., Laudanna C., Gentzsch M., Lukacs G.L., Pedemonte N., Hirsch E.
A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases
Science Translational Medicine, vol. 14, (no. 638)
2022
Philp A.R., Miranda F., Gianotti A., Mansilla A., Scudieri P., Musante I., Vega G., Figueroa C.D., Galietta L.J.V., Sarmiento J.M., Flores C.A.
KCa3.1 differentially regulates trachea and bronchi epithelial gene expression in a chronic-asthma mouse model
Physiological Genomics, vol. 54, (no. 7), pp. 273-282
2021
Ferrera L., Capurro V., Delpiano L., Gianotti A., Moran O.
The application of bicarbonate recovers the chemical-physical properties of airway surface liquid in cystic fibrosis epithelia models
Biology, vol. 10, (no. 4)
2020
Pedemonte N., Bertozzi F., Caci E., Sorana F., Fruscia P.D., Tomati V., Ferrera L., Rodriguez-Gimeno A., Berti F., Pesce E., Sondo E., Gianotti A., Scudieri P., Bandiera T., Galietta L.J.V.
Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel
Science advances, vol. 6, (no. 8)
2020
Brindani N., Gianotti A., Giovani S., Giacomina F., Di Fruscia P., Sorana F., Bertozzi S.M., Ottonello G., Goldoni L., Penna I., Russo D., Summa M., Bertorelli R., Ferrera L., Pesce E., Sondo E., Galietta L.J.V., Bandiera T., Pedemonte N., Bertozzi F.
Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1 H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators
Journal of Medicinal Chemistry, vol. 63, (no. 19), pp. 11169-11194
2020
Vega G., Guequen A., Philp A.R., Gianotti A., Arzola L., Villalon M., Zegarra-Moran O., Galietta L.J.V., Mall M.A., Flores C.A.
Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease
JCI insight, vol. 5, (no. 16)
2020
Gianotti A., Capurro V., Delpiano L., Mielczarek M., Garcia-valverde M., Carreira-barral I., Ludovico A., Fiore M., Baroni D., Moran O., Quesada R., Caci E.
Small molecule anion carriers correct abnormal airway surface liquid properties in cystic fibrosis airway epithelia
International Journal of Molecular Sciences, vol. 21, (no. 4)
2018
Gianotti A., Delpiano L., Caci E.
In vitro methods for the development and analysis of human primary airway epithelia
Frontiers in Pharmacology, vol. 9, (no. OCT)
2016
Gorrieri G., Scudieri P., Caci E., Schiavon M., Tomati V., Sirci F., Napolitano F., Carrella D., Gianotti A., Musante I., Favia M., Casavola V., Guerra L., Rea F., Ravazzolo R., Di Bernardo D., Galietta L.J.V.
Goblet Cell Hyperplasia Requires High Bicarbonate Transport to Support Mucin Release
Scientific Reports, vol. 6
2016
Scudieri P., Musante I., Gianotti A., Moran O., Galietta L.J.V.
Intermolecular interactions in the TMEM16A dimer controlling channel activity
Scientific Reports, vol. 6
2016
Gianotti A., Ferrera L., Philp A.R., Caci E., Zegarra-Moran O., Galietta L.J.V., Flores C.A.
Pharmacological analysis of epithelial chloride secretion mechanisms in adult murine airways
European Journal of Pharmacology, vol. 781, pp. 100-108
2016
Gianotti A., Capurro V., Scudieri P., Galietta L.J.V., Moran O., Zegarra-Moran O.
Pharmacological rescue of mutant CFTR protein improves the viscoelastic properties of CF mucus
Journal of Cystic Fibrosis, vol. 15, (no. 3), pp. 295-301
2015
Capurro V., Gianotti A., Caci E., Ravazzolo R., Galietta L.J.V., Zegarra-Moran O.
Functional analysis of acid-activated Cl- channels: Properties and mechanisms of regulation
Biochimica et Biophysica Acta - Biomembranes, (no. Part A), pp. 105-114
2015
Tomati V., Sondo E., Armirotti A., Caci E., Pesce E., Marini M., Gianotti A., Ju Jeon Y., Cilli M., Pistorio A., Mastracci L., Ravazzolo R., Scholte B., Ronai Z., Galietta L.J.V., Pedemonte N.
Genetic Inhibition of the Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated to F508del Cystic Fibrosis Mutation
Scientific Reports, vol. 5
2015
Pesce E., Bellotti M., Liessi N., Guariento S., Damonte G., Cichero E., Galatini A., Salis A., Gianotti A., Pedemonte N., Zegarra-Moran O., Fossa P., Galietta L.J.V., Millo E.
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis
European Journal of Medicinal Chemistry, vol. 99, pp. 14-35
2015
Caci E., Scudieri P., Carlo E.D., Morelli P., Bruno S., De Fino I., Bragonzi A., Gianotti A., Sondo E., Ferrera L., Palleschi A., Santambrogio L., Ravazzolo R., Galietta L.J.V.
Upregulation of TMEM16A protein in bronchial epithelial cells by bacterial pyocyanin
PLoS ONE, vol. 10, (no. 6)
2013
Gianotti A., Melani R., Caci E., Sondo E., Ravazzolo R., Galietta L.J.V., Zegarra-Moran O.
Epithelial sodium channel silencing as a strategy to correct the airway surface fluid deficit in cystic fibrosis
American Journal of Respiratory Cell and Molecular Biology, vol. 49, (no. 3), pp. 445-452
2012
Scudieri P., Caci E., Bruno S., Ferrera L., Schiavon M., Sondo E., Tomati V., Gianotti A., Zegarra-Moran O., Pedemonte N., Rea F., Ravazzolo R., Galietta L.J.V.
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia
Journal of Physiology, vol. 590, (no. 23), pp. 6141-6155